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platelet rich plasma



Osteoarthritis and Tendinopathies, Osteoarthritis, Knee, Shoulder, Wrist, Hip, Ankle, Elbow, Chronic Tendinopathies, Epicondylitis, Epitrocleitis, Rotator cuff, Patellar and yarrow tendinitis, Gonarthrosis, Coxarthrosis, Rhizo

The growth factors of platelet-derived (PRP) are used in some specific pathologies of the skeletal muscle in order to accelerate the natural healing process and to promote tissue regeneration.

The infiltrative therapy with platelet gel (containing growth factors ) combined with adequate rehabilitation exercises is particularly indicated in sportsmen and in patients, even non-sportsmen, with joint, tendon and muscle pathologies (for example arthrosis, tendinopathies, strains.).

Generally the best results are obtained in patients under the age of 50. The technique is simple and minimally invasive and consists in the infiltration of the autologous platelet gel, containing the growth factors , directly inside the joints or in tendons, muscles and ligaments. The autologous platelet gel is obtained through the centrifugation of peripheral venous blood obtained by simply drawing 20 or 60 cc of blood from the patient himself.

What are platelet-derived growth factors?
The growth factors are substances released from platelets can significantly affect the process of repair of musculoskeletal tissues. These factors promote healing processes by calling immune cells and progenitor cells back to the injury site, which are stimulated to regenerate the tissue. They also stimulate tissue cellsdamaged by the synthesis of proteins necessary for the restarting process. The main growth factors are: bFGF (basic fibroblastic growth factor), PDGF (platelet-derived growth factor), IGF (insuline-like growth factor), EGF (epidermal growth factor), VEGF (vascular endothelial growth factor), TGF- ß (transforming growth factor-beta).


The goal of platelet gel treatment is to stimulate and / or speed up the healing of connective tissues such as cartilage, tendon and muscle, at the same time promoting pain reduction, functional increase and the formation of breakdown tissue. more physiological.

2-3 ° degree muscle injuries

Tendon and ligament injuries (shoulder, knee, ankle)

Chronic tendinopathies (epicondylitis, epithrocleitis, rotator cuff tendinopathy, patellar tendinitis, yarrow tendonitis, posterior tibial tendinopathy ..)

Cartilage injuries (shoulder, elbow, wrist, hip, knee, ankle)

The treatment is contraindicated in case of systemic neoplasms and infectious diseases in the acute phase. Treatment must also be refrained in the case of thrombocytopenia and in the case of acute joint inflammation, until this has resolved.

Side effects
Generally infrequent, transient increase in pain and inflammation may occasionally occur (in the first 24-48 hours), easily treatable with cryotherapy (ice pack for 15 minutes, 2-3 times a day) and a mild analgesic (paracetamol).

Tendon and ligament muscle injuries, Muscle injuries, Tendon injuries, Ligament injuries


The PRP applied to the lesion site provides significantly higher quantities of these mediators with the aim of facilitating and accelerating the healing processes, also increasing local vascularization by stimulating the formation of new vessels.
The goal of PRP infiltrative therapy is to reduce or eliminate pain and inflammation, recover functional limitation and reduce the need for surgery.

Therapeutic indications
The indications are numerous. We perform the treatment with PRP for:
Chronic tendon pathologies: yarrow tendinopathy, patellar tendinopathy, plantar fasciitis, shoulder tendinopathy, epicondylitis, epitrocleitis, ischial tendinopathy, intra-articular pathologies: gonarthrosis, coxarthrosis, rhizoatrosis.


In tendon pathologies, infiltration is carried out under ultrasound guidance and involves 1 or 2 punctures at the injury site, with multiple deposits, so that the needle remains in place making small movements to reach different points in the injury area. Infiltration is performed without anesthesia. Treatment is usually well tolerated, although generally painful. At the end, the infiltration area is medicated and a compression bandage is applied which the patient can remove the same evening. The treatment is compatible with all the daily life activities carried out before carrying out the infiltration, so it is possible to walk, drive without the need for assistance, without overloading the affected district. It is recommended that non-steroidal anti-inflammatory drugs (NSAIDs) be avoided for at least 5 days before and 3 days after infiltration due to their possible interference with the platelet activation mechanism. Paracetamol and application of ice are recommended if the pain of the underlying disease requires it.

The PRPit is produced from autologous blood, that is from blood taken from the same patient with prp tubes who receives it and for this reason it is considered safe and biocompatible. In fact, the risk of transmission of infectious diseases and immune system reactions is eliminated. After infiltration, the characteristic disturbances of any infiltration may occur in the treated area, also in relation to the volume of the platelet concentrate introduced, so it is advisable to limit the functional activity for the following 24/48 and local ice application. A possible carcinogenic effect has been hypothesized on the basis of the ability of growth factors to stimulate cell proliferation and differentiation, but this hypothesis has not yet been proven by any scientific study.

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